Description

IGF-1 LR3 is a recombinant modified form of insulin-like growth factor I supplied for controlled laboratory and analytical research.

The LR3 construct differs structurally from native IGF-1 by adding a 13-amino-acid extension at the N-terminus and substituting arginine for glutamic acid at the third position of the native IGF-1 sequence.

These defined structural modifications produce an 83-amino-acid research protein with distinct molecular characteristics that can be studied in biochemical, receptor-associated, protein-interaction, and analytical research systems.

Research Applications

IGF-1 LR3 may be examined in controlled non-clinical laboratory settings involving:

• Recombinant protein characterization
• Ligand-receptor interaction studies
• Molecular signaling research
• Protein structure-function analysis
• Analytical comparison with related IGF proteins
• Cellular research models
• Protein stability investigations

Any observations should remain specific to the study design and experimental system. Do not interpret research findings as evidence of therapeutic effectiveness, clinical safety, performance enhancement, or suitability for human use.

Structural Characteristics

IGF-1 LR3 is structurally distinct from native human IGF-1.

Key characteristics include:

• 83 total amino acids
• A 13-residue N-terminal extension
• An arginine substitution at position corresponding to residue 3 of native IGF-1
• Multiple cysteine residues associated with the characteristic IGF protein structure
• Recombinant production commonly using microbial expression systems

Confirm the exact recombinant construct and expression system in the supplier’s product documentation.

Analytical Identification

Analytical characterization may include:

• Protein identity confirmation
• Amino-acid sequence verification
• Molecular mass analysis
• Purity assessment
• Chromatographic testing
• Electrophoretic characterization
• Lot-specific quality testing

Sigma-Aldrich lists the calculated molecular weight at approximately 9.11 kDa, while apparent molecular weight measured by SDS-PAGE may differ depending on analytical conditions.

Specifications & Documentation

Lot-specific documentation should be reviewed for:

• Protein identity
• Recombinant source
• Amino-acid sequence
• Molecular weight
• Purity specification
• Analytical results
• Lot or batch information
• Certificate of Analysis
• Storage requirements

Authenticated product-specific documentation should take precedence over generic reference values.

Storage & Handling

Store according to the conditions specified on the product label and Certificate of Analysis. Maintain appropriate laboratory controls and protect the material from environmental conditions that may compromise protein integrity.

Handle according to established laboratory procedures appropriate for recombinant research proteins.

Research Use Only

IGF-1 LR3 is supplied exclusively for laboratory research, analytical testing, and scientific reference purposes.

Disclaimer

For research use only. Not for human or veterinary use. Not intended for consumption, administration, performance enhancement, diagnosis, treatment, mitigation, cure, or prevention of any disease. No therapeutic, medical, hormonal, or clinical claims are made or implied. All information is supplied solely for scientific identification, documentation, and research reference.